Updated: Aug 24 2018Vacuuming will be most effective if the speakers have been unplugged for six to twelve hours (i.e. overnight). You need not worry about the vacuum pressure damaging the "delicate" membrane. It is extraordinarily durable. Dirt and dust may be vacuumed off with a brush attachment connected to your vacuum cleaner, or you may blow them off with compressed air. When vacuuming or blowing off your panels do so to both sides, but focus the majority of your attention on the front of the panels.